The challenge is simply our will to attain out to every child. And older children struggle to thrive when their bodies and minds are weakened by lack of these tiny but essential essentials, holding back productivity and national economic development. The return on our investment shall be huge. While it offers been known for years that having less key minerals and vitamins inflicts anaemia, cretinism and blindness, attention within the last decade has shifted to the economic and social impact on populations. Vitamin and mineral deficiencies impair intellectual development, compromise immune systems, provoke birth defects and consign millions to living below their full physical and mental potential.Several novel paired-domain missense and transactivating domain splice-site and frameshift mutations had been identified. Each of the paired-domain mutations is definitely predicted to bring about impaired binding of PAX5 to DNA, or disruption of the interaction of PAX5 with ETS1, which is necessary for high-affinity binding of PAX5 to target DNA sequences21 . Among the 221 patients, the complete IKZF1 locus was deleted in 16 ; in 47 additional patients, a subgroup of exons or the genomic area instantly upstream of IKZF1 was deleted. In 20 of these 47 patients, there is a deletion of coding exons 3 through 6, which outcomes in expression of a dominant-negative type of IKAROS, Ik6, which lacks all N-terminal, DNA-binding zinc fingers.5 We also identified six novel missense, frameshift, and non-sense IKZF1 mutations , each which is predicted to impair IKAROS function.