Goals of the Alliance for Well balanced Pain Management Ensure people with or suffering from pain have appropriate usage of integrated, effective and safe care, such as physical rehabilitation and therapy, psychological counseling, cultural support, medication and additional complementary approaches. Reinforce the critical need to securely prescribe, dispense, take, store and dispose of prescription medications with an try to reduce abuse, misuse and diversion. Support organizations and people who talk about a common goal to lessen pain, improve treatment and advocate for responsible use of medicine.Owing to competing trials, patients with stage III disease no residual lesions higher than 1 cm in maximal size were initially excluded, but after a protocol modification they were permitted. All individuals provided written informed consent before enrollment. Study Design The study was a double-blind, placebo-controlled phase 3 trial . The protocol is available at NEJM.org. The authors wrote the manuscript and take responsibility for the precision and completeness of the reported data and for the fidelity of the are accountable to the protocol.