Sites maintained compliance with MEDICAL HEALTH INSURANCE Accountability and Portability Work regulations. Eligible sufferers provided written informed consent. Study Design Both studies were multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 trials; the FIXTURE study was also active-controlled. From June 2011 through April 2013 at 88 sites worldwide The ERASURE research was conducted; from June 2011 through June 2013 at 231 sites the FIXTURE study was conducted. The participating research sites are outlined in the Supplementary Appendix. Each scholarly study consisted of a screening period of 1 to four weeks, a 12-week induction period, a 40-week maintenance period, and an 8-week follow-up period .The reported MID is around 0.08 for the self-report questionnaire and 7 factors for the visual-analogue scale. We recorded all adverse events, hospitalizations, and deaths. Each suspected acute exacerbation was adjudicated by a central committee in a blinded style. Study Visits Screening procedures included the taking of an in depth history to eliminate known factors behind interstitial lung disease, a physical examination , spirometry, and measurements of lung volume on plethysmography, carbon monoxide diffusion capacity, and arterial blood vessels gases.