We repeated the analyses in the subgroup of individuals who were not contained in registration trials for previously untreated patients. An independent statistician who was simply unaware of item types repeated all results by way of Cox proportional-hazards regression versions. Results Patients A complete of 648 patients were qualified to receive the study. Of these, 17 individuals were excluded because of pending educated consent, and 25 sufferers had been excluded by the investigators for several other reasons .ABC’s 19-web page monograph on Pycnogenol was written by toxicologist Heather S. Oliff, Ph.D., and it was formally peer reviewed by scientific and medical experts for its accuracy. ABC emphasizes that the publication of the Pycnogenol monograph isn’t an endorsement or suggestion of the ingredient or the maker. ABC has had a long background of documenting the specific herbal products and things that have already been clinically tested, stated Blumenthal. Within our nonprofit educational mission, we believe that it is in the general public interest to recognize clinically tested natural plant-based products and elements which the scientific literature suggests are safe and helpful.