Pim A medication .L. Tonino, M.D., Bernard De Bruyne, M.D., Ph.D., Nico H.J. Pijls, M.D., Ph.D., Uwe Siebert, M.D., M.P.H., Sc.D., Fumiaki Ikeno, M.D., Marcel van `t Veer, M.Sc., Volker Klauss, M.D., Ph.D., Ganesh Manoharan, M.D.D., Ph.D., Keith G. Oldroyd, M.D., Peter N. Ver Lee, M.D., Philip A. MacCarthy, M.D., Ph.D., and William F. Fearon, M.D. For the FAME Study Investigators: Fractional Stream Reserve versus Angiography for Guiding Percutaneous Coronary Intervention The presence of myocardial ischemia is an important risk factor for a detrimental clinical outcome.1-3 Revascularization of stenotic coronary lesions that induce ischemia may improve a patient’s useful status and outcome.3-5 For stenotic lesions that usually do not induce ischemia, however, the advantage of revascularization is less clear, and medical therapy alone is likely to be effective equally.6,7 With the introduction of drug-eluting stents, the %age of patients with multivessel coronary artery disease in whom percutaneous coronary intervention is conducted has increased.8,9 Because drug-eluting stents are costly and are associated with potential late complications, their right use is crucial.10,11 However, in patients with multivessel coronary artery disease, determining which lesions trigger ischemia and warrant stenting could be difficult.
An initial episode of confirmed vaccine-type community-acquired pneumonia was documented in 49 individuals in the PCV13 group and 90 individuals in the placebo group . A first episode of verified nonbacteremic and noninvasive vaccine-type community-acquired pneumonia was documented in 33 participants in the PCV13 group and 60 individuals in the placebo group , and an initial episode of vaccine-type invasive pneumococcal disease was documented in 7 individuals in the PCV13 group and 28 participants in the placebo group . We also found that the vaccine had significant efficacy with regards to the same three end factors in the modified intention-to-treat population .