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Things aren’t looking good for Avandia’s chances at the brief moment. This morning, the New York Situations led with the tale of a damning clinical trial that GlaxoSmithKline sought to cover. In that study, conducted in 1999, GSK found that Avandia had a higher risk of causing heart problems compared to its chief rival, Actos. Since that time, independent studies have called attention to Avandia’s danger and confirmed that it’s riskier. How different will be the two medicines? Pharmacologically speaking, GSK’s Avandia and Takeda’s Actos are quite similar.