And Qiang Zhang medicina.

W. Jack Rejeski, Ph medicina .D., Edward H. Ip, Ph.D., Alain G. Bertoni, M.D., George A. Bray, M.D., Gina Evans, Ph.D., Edward W. Gregg, Ph.D., and Qiang Zhang, M.S. For the Look AHEAD Analysis Group: Lifestyle Change and Flexibility in Obese Adults with Type 2 Diabetes The growing prevalence of type 2 diabetes mellitus can be an ominous health threat in the United Says1,2 and globally.3 Surveillance data from the Centers for Disease Control and Prevention cite type 2 diabetes as largely an illness of aging,4 and its own prevalence might escalate as the population gets older.5,6 An insidious consequence of aging in people with type 2 diabetes is physical disability,7 the loss of mobility particularly.8 Reduced mobility puts patients at risk for lack of independence,9 leads to muscle reduction ,10 and compromises the quality of life.11 With increasing age in the overall population, the risk of mobility-related problems increases with the known degree of obesity12-14 and physical inactivity.15,16 Equally compelling data show that older adults with type 2 diabetes have two times the prevalence of disability in mobility-related activities, as compared with those without the condition.17 An increasing body-mass index further increases the risk.18 The ongoing Look AHEAD study, a multicenter, randomized, controlled trial enrolling more than 5000 obese or overweight persons with type 2 diabetes, was designed to determine whether intentional weight loss would reduce morbidity and mortality from cardiovascular causes.

Evans, Ph.D., David C. Montefiori, Ph.D., Chitraporn Karnasuta, Ph.D., Ruengpueng Sutthent, M.D., Ph.D., Hua-Xin Liao, M.D., Ph.D., Anthony L. DeVico, Ph.D., George K. Lewis, Ph.D., Constance Williams, B.S., Abraham Pinter, Ph.D., Youyi Fong, Ph.D., Holly Janes, Ph.D., Allan DeCamp, M.S., Yunda Huang, Ph.D., Mangala Rao, Ph.D., Erik Billings, Ph.D., Nicos Karasavvas, Ph.D., Merlin L. Robb, M.D., Viseth Ngauy, M.D., Mark S. De Souza, Ph.D., Robert Paris, M.D., Guido Ferrari, M.D., Robert T. Bailer, Ph.D., Kelly A. Soderberg, Ph.D., Charla Andrews, Sc.M., Phillip W. Berman, Ph.D., Nicole Frahm, Ph.D., Stephen C. De Rosa, M.D., Michael D. Alpert, Ph.D., Nicole L. Yates, Ph.D., Xiaoying Shen, Ph.D., Richard A. Koup, M.D., Punnee Pitisuttithum, M.D., D.T.M.H., Jaranit Kaewkungwal, Ph.D., Sorachai Nitayaphan, M.D., Ph.D., Supachai Rerks-Ngarm, M.D., Nelson L.