African-Americans more likely to die from colorectal malignancy than Caucasians, says new study New research published in the November issue of the Journal of the American University of Surgeons implies that African-American patients with colorectal cancer are more likely to be diagnosed with advanced disease and so are less inclined to undergo surgical techniques compared with Caucasians, suggesting that improvements in rates and screening of operation may reduce variations in colorectal cancers outcomes for African-Americans.This finding may prove to have significant implications for decisions about treatment. In our current research, the strongest effect of aspirin use was in patients who had tumors with both PIK3CA mutation and PTGS2 expression. We should interpret these total results with caution, however, because of the multiple subgroup analyses and limited statistical power. Non-etheless, our current findings are not inconsistent with those of our prior research,8 which demonstrated a strong antitumor aftereffect of aspirin on PTGS2-positive colorectal cancer. Experimental evidence supports cross-talk between the PTGS2 and PI3K pathways.20,21 In combination with the experimental observation that aspirin can induce cell apoptosis through PTGS2-independent pathways,38,39 our data might provide support for an antitumor aftereffect of aspirin in addition to that of PTGS2 inhibition, although the exact mechanisms have to be clarified.33,40 The frequencies of molecular features such as a advanced of microsatellite instability and extensive CpG island methylation, as well as PIK3CA and BRAF mutations, appear to increase continuously from the rectum to ascending colon.33 Considering a gradual changeover of gut biogeography, the inhibitory aftereffect of aspirin on cancers varies according to both the specific site of the tumor and its own molecular features.