Radiation Damage to the GI System The intestinal epithelium, a single coating of cells lining the top of GI lumen, is in charge of vital features of nutrient absorption, maintaining fluid and electrolyte stability and protection of the body from bacteria, bacterial poisons and non absorbed components. The useful integrity of the GI program is taken care of via incessant creation of epithelial cells from specific stem cells located in crypts at the bottom of the epithelium. High-dose, total-body irradiation can result in a lethal GI syndrome that results in significant morbidity and mortality within times consequent to eliminating of the crypt stem cells and loss of the protecting and absorptive epithelial barrier. There are no FDA-approved biologics or drugs to take care of the acute GI syndrome..Another steps necessary for the advancement of the XRX-001 vaccine consist of evaluation of the durability of the antibody response reported in today’s trial and initiation of a double-blind, phase 2 clinical study.
A therapeutic method for failed bladder augmentation in children This study by Vajda et al investigated the potential causes leading to the deterioration of a previously successful bladder augmentation. Between 1988 and 2004, 136 bladder augmentations were performed in this scholarly study out of Turkey and Hungary. Re-augmentation was necessary in 2 individuals after colocystoplasty and in 3 after gastrocystoplasty.